Endocrine Abstracts

Insulin-like factor 3 (INSL3) is a testis-specific, Leydig cell derived hormone, which we recently demonstrated to play a role in bone metabolism. Young men with mutations in the gene for the INSL3 receptor (Relaxin family peptide 2, RXFP2) are at risk of reduced bone mass and osteoporosis. Consistent with the human phenotype, bone analyses of Rxfp2−/− mice showed decreased bone volume, alterations of the trabecular bone, reduced mineralizing surface, bo...